Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute coronary syndrome Age: Adult Condition: Loading dose (following ACS event) |
Dose: Oral Tablet – 180 mg (two 90 mg tablets) Frequency: once Note: Administer by mouth. Administer with aspirin: Initial aspirin loading dose of 325 mg. |
|
Indication: Acute coronary syndrome Age: Adult Condition: Maintenance dose (for first year following ACS event) |
Dose: Oral Tablet – 90 mg Frequency: twice daily Note: Administer by mouth. Administer with aspirin: maintenance dose of aspirin of 75-100 mg/day; DO NOT exceed aspirin dose of 100 mg/day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dose: Note: No dosage adjustment needed |
Administration
- Can take with or without food
- Take at regular times
Side Effect
- Dyspnea (13.8%)
- Bleeding
- Headache (6.5%)
- Cough (4.9%)
- Dizziness (4.5%)
- Nausea (4.3%)
- Atrial fibrillation (4.2%)
- Hypertension (3.8%)
- Noncardiac chest pain (3.7%)
- Diarrhea (3.7%)
- Back pain (3.6%)
- Hypotension (3.2%)
- Fatigue (3.2%)
- Chest pain (3.1%)
- Syncope (1.7%)
- Dyspena (0.9%)
- Bleeding
- Non-CABG related bleeds
- Total bleeds (major + minor) (8.7%)
- Major bleeds (4.5%)
- Fatal/life-threatening (2.1%)
- Fatal (0.2%)
- Intracranial (fatal/life-threatening) (0.3%)
- CABG related bleeds
- Total major bleeds (85.8%)
- Major bleeds when antiplatelet therapy stopped 5 days before CABG (75%)
- Fatal/life-threatening (48.1%)
- Fatal (0.9%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aminocaproic acid, tranexamic acid, recombinant clotting factor VIIa
|
May augment haemostasis
|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban), fibrinolytics, ketoconazole, clarithromycin, nefazodone, ritonavir, atazanavir, rifampin, dexamethasone, phenytoin, carbamazepine, phenobarbital, simvastatin, digoxin
|
Interactions mentioned but specific effects not detailed
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Intracranial Hemorrhage History
|
Risk of recurrent bleeding
|
|
Active Bleeding
|
Risk of uncontrolled bleeding
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Protect from light & moisture. Store below 25° C. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.