Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Parkinson Disease Age: Adult Condition: Initial treatment |
Dose: by mouth – 50 mg Frequency: once daily Note: Indicated as add-on treatment for patients who are currently taking levodopa/carbidopa and experiencing “off” episodes |
|
Indication: Parkinson Disease Age: Adult Condition: Maintenance treatment |
Dose: by mouth – 100 mg Frequency: once daily Note: May increase dose to 100 mg once daily after 2 weeks, based on individual need and tolerability. Doses greater than 100 mg/day have not shown additional benefit. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Form – Not specified Note: No approved pediatric dosage available |
Administration
- Take with or without food
- Take at same time each day
Side Effect
- Dyskinesia (17-21%)
- Hypertension (5-7%)
- ALT or AST increased to More than ULN (5-7%)
- Fall (4-6%)
- Nausea (3-6%)
- Insomnia (1-4%)
- Orthostatic hypotension (2%)
- Anxiety (2%)
- Cough (2%)
- Dyspepsia (2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Linezolid
|
May result in increased blood pressure, including hypertensive crisis
|
|
Meperidine, methadone, tramadol, SNRIs, tricyclic Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), tetracyclic Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), triazolopyridine Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), cyclobenzaprine, methylphenidate, amphetamine and derivatives, St John's wort
|
Could result in life-threatening serotonin syndrome
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity to Safinamide
|
Risk of allergic reactions including tongue/mouth swelling and breathing difficulty
|
|
Severe Hepatic Impairment
|
Risk of drug toxicity due to impaired liver function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.