Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression Age: Adult |
Dose: Oral – Initially, 15 mg daily; may be increased gradually depending on clinical response Frequency: single dose, preferably at bedtime, or in 2 divided doses Duration: Change dose at intervals of at least 1-2 weeks Note: Usual effective dose: 15-45 mg daily |
|
Indication: Depression Age: Elderly |
Dose: Oral – 7.5 mg/day Frequency: by mouth at bedtime Duration: increase by 7.5-15 mg/day no more frequently than every 1-2 weeks Note: not to exceed 45 mg/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment (Creatinine Clearance less than 39 mL/min) |
Dose: Not specified Note: Clearance is reduced; monitor closely |
Administration
- May be taken with or without food
- Take in the evening before bed
Side Effect
- Somnolence (54%)
- Weight gain (More than 7% increase in Less than 49% of pediatric patients)
- Xerostomia (25%)
- Increased appetite (17%)
- Constipation (13%)
- Asthenia (8%)
- lWeakness (8%)
- Weight gain (More than 7% increase in 8% of adults)
- Dizziness (7%)
- Serum TGs increased (6%)
- Dream disorder (4%)
- Disturbance in thinking (3%)
- ALT increased (2%)
- Peripheral edema (2%)
- Myalgia (2%)
- Confusion (2%)
- Urinary frequency (2%)
- Tremor (2%)
- Back pain (2%)
- Dyspnea (1%)
- Mania (0.2%)
- Grand mal seizure (less than 0.1%)
- Depression exacerbation
- Status epilepticus
- Suicidal thoughts
- suicide (rare)
- Agranulocytosis
- Neutropenia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cimetidine
|
Increased bioavailability
|
|
Alcohol, Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam)
|
Potentiation of sedative effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Known Hypersensitivity to Mirtazapine
|
Risk of severe allergic reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep away from light and moisture. Store below 30º C. Keep all medicine out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.