Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Parkinson Disease Age: Adults Condition: Experiencing "OFF" episodes, Hepatic impairment Mild (Child-Pugh A) |
Dose: by mouth – 20 mg Frequency: once daily Note: May increase to maximum of 40 mg by mouth once daily. Initial dose titration not required. No dosage adjustment required. |
|
Indication: Parkinson Disease Age: Adults Condition: Experiencing "OFF" episodes, Hepatic impairment Moderate (Child-Pugh B) |
Dose: by mouth – 20 mg Frequency: once daily Note: May increase to maximum of 40 mg by mouth once daily. Initial dose titration not required. Not to exceed 20 mg by mouth once daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Mild, moderate, or severe (CrCl 15-89 mL/min) |
Dose: No dosage adjustment required Note: No dosage adjustment required |
|
Condition: ESRD (CrCl less than 15 mL/min) or ESRD requiring hemodialysis |
Dose: Not studied Note: Not studied |
Administration
- Take at regular intervals
- Take as directed
Side Effect
- Dyskinesia (15-17%)
- Constipation (5-6%)
- Nausea (4-6%)
- Dizziness (3-6%)
- Hallucination (2-6%)
- Insomnia (1-6%)
- Decreased appetite (1-3%)
- Increased alkaline phosphatase (1-2%)
- Increased blood glucose (1-2%)
- Increased blood urea (1-2%)
- Upper respiratory tract inflammation (1-2%)
- Rash (1-2%)
- Diarrhea (1-2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A4 substrates
|
May affect at higher doses
|
|
Strong CYP3A4 inhibitors
|
Limit to 20 mg daily
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.