Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Active Tuberculosis Disease Age: Adult |
Dose: Oral – 5 mg/kg Frequency: once daily Note: not to exceed 300 mg once daily; used in multi-drug regimen containing rifampin (or ribabutin or rifapentin), pyrazinamide, and ethambutol |
|
Indication: Active Tuberculosis Disease Age: Adult |
Dose: Oral – 15 mg/kg Frequency: 1-3 times/week Note: not to exceed 900 mg; used in multi-drug regimen containing rifampin (or ribabutin or rifapentin), pyrazinamide, and ethambutol |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Active Tuberculosis Disease |
Dose: Oral – 10-15 mg/kg Frequency: once daily Note: not to exceed 300 mg/day; used in multi-drug regimen |
|
Indication: Active Tuberculosis Disease |
Dose: Oral – 20-30 mg/kg Frequency: 2 times/week Note: up to 900 mg; used in multi-drug regimen |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Severe |
Dose: Not mentioned Note: Dose reduction may be needed |
Administration
- Take on empty stomach
- 1hr before/2hrs after food
Side Effect
- Mild incr LFTs (10-20%)
- Peripheral neuropathy (dose-related incidence, 10-20% incidence with 10 mg/kg/d) Loss of appetite
- Nausea
- Vomiting
- Stomach pain
- Weakness
- Dizziness
- Slurred speech
- Lethargy
- Progressive liver damage (increases with age 2.3% in pts More than 50 year old)
- Hyperreflexia
- Agranulocytosis
- Anemia
- Megaloblastic anemia
- Thrombocytopenia
- Systemic lupus erythematosus
- Seizure
- Hepatotoxicity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Carbamazepine, Ethosuximide, Primidone, Phenytoin, Diazepam, Triazolam, Chlorzoxazone, Theophylline, Disulfiram
|
Inhibit the hepatic metabolism
|
|
Enflurane
|
Increased metabolism resulting in potentially nephrotoxic levels of fluoride
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute Liver Disease, Previous INH-induced hepatitis
|
Can cause severe liver damage
|
|
Acute Liver Disease
|
Can cause severe liver damage
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.