Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Pain, Fever, or Dysmenorrhea |
Dose: by mouth – 200-400 mg Frequency: every 4-6 hours Note: not to exceed 1.2 g unless directed by physician |
|
Indication: Inflammatory Disease |
Dose: by mouth – 400-800 mg Frequency: every 6-8 hours Note: not to exceed 3.2 g/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Fever Age: 6 months to 12 years |
Dose: Oral dose – 5-10 mg/kg/dose Frequency: every 6-8 hours Note: by mouth (oral); not to exceed 40 mg/kg/day |
|
Indication: Pain |
Dose: Oral dose – 4-10 mg/kg/dose Frequency: every 6-8 hours Note: by mouth (oral); not to exceed 40 mg/kg/day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Significantly impaired renal function |
Dose: Not specified Note: Monitor closely; consider reduced dosage if warranted |
Administration
- Take with food
- Regular timing
Side Effect
- Dizziness (3-9%)
- Epigastric pain (3-9%)
- Heartburn (3-9%)
- Constipation (1-3%)
- Nausea (3-9%)
- Rash (3-9%)
- Tinnitus (3-9%)
- Edema (1-3%)
- Fluid retention (1-3%)
- Headache (1-3%)
- Vomiting (1-3%)
- Acute renal failure (sometimes with acute tubular necrosis or hyperkalemia, polyuria, azotemia, cystitis, hematuria, decreased creatinine clearance, elevations in blood urea nitrogen (BUN) or creatinine without other manifestations of renal failure)
- Agranulocytosis
- Aplastic anemia
- Erythema multiforme
- Erythematous macular rashes
- Exfoliative dermatitis
- Hemolytic anemia (with or without positive direct antiglobulin test results)
- Neutropenia
- Thrombocytopenia (with or without purpura)
- Toxic epidermal necrolysis (Lyell syndrome) and photosensitivity reactions
- Severe CV thrombotic events
- Severe GI bleeding
- ulceration and perforation
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Warfarin, Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone), SSRIs, aspirin
|
Increased risk of GI bleeding
|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene)
|
May reduce natriuretic effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Peptic Ulcer
|
Can cause dangerous bleeding
|
|
Congenital Heart Disease In Neonates
|
Can worsen heart condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.