Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oral Type 2 Diabetes Mellitus Condition: Patients not currently treated with Metformin |
Dose: Tablet – 50 mg/500 mg Frequency: twice daily Note: Maximum daily dose is Sitagliptin 100 mg/metformin 2000 mg. |
|
Indication: Oral Type 2 Diabetes Mellitus Condition: Patients already treated with Metformin |
Dose: Tablet – 50 mg Sitagliptin and the dose of Metformin already being taken Frequency: twice daily Note: The starting dose should provide 100 mg total daily dose of sitagliptin. Maximum daily dose is Sitagliptin 100 mg/metformin 2000 mg. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: Tablet – Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: eGFR less than 30 mL/min/1.73 m2 |
Dose: Not specified Note: Contraindicated. If eGFR falls below 30 mL/min/1.73 m2 while taking metformin, discontinue the drug. |
|
Condition: eGFR 30-45 mL/min/1.73 m2 |
Dose: Not specified Note: Not recommended to initiate treatment. If eGFR falls below 45 mL/min/1.73 m2 while taking metformin, risks and benefits of continuing therapy should be evaluated. |
Administration
- Take with food
- Take with meals to minimize GI effects
Side Effect
- Abdominal pain (2.2%)
- Diarrhea (2.4%)
- Hypoglycemia (2.1%)
- Nausea (1.3%)
- Exfoliative disorder of skin of scalp
- Stevens-Johnson syndrome
- Lactic acidosis (rare)
- Anaphylaxis/hypersensitivity reaction
- Rhabdomyolysis
- Acute renal failure
- Angioedema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Same as Metformin Hydrochloride
|
Same effects as Metformin Hydrochloride
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Renal Dysfunction (Males)
|
Impairs drug elimination
|
|
Renal Dysfunction (Females)
|
Impairs drug elimination
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 25°C in a dry place away from light. Keep the medicines in a safe place, out of the reach of children. Do not use later than the date of expiry. To be dispensed only on the prescription of a registered physician.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.