Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prevention of Chemotherapy-induced Nausea and Vomiting Age: Adult |
Dose: Intravenous – 0.25 mg Frequency: single dose Note: To be given over 30 seconds and 30 minutes before chemotherapy. Do not repeat within 7 days. Hepatic impairment: Dose adjustment not necessary. |
|
Indication: Prevention of Chemotherapy-induced Nausea and Vomiting Age: Adult |
Dose: Tablet/capsule – 0.5 mg Frequency: approximately 1 hour before the start of chemotherapy, then once daily Note: Hepatic impairment: Dose adjustment not necessary. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prevention of Postoperative Nausea and Vomiting Age: less than 18 years |
Dose: Not established Note: Safety and efficacy not established |
|
Indication: Prevention of Chemotherapy-induced Nausea and Vomiting Age: less than 1 month |
Dose: Not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dose adjustment not necessary Note: Renal impairment: Dose adjustment not necessary |
Administration
- Mix with approved solutions (5% glucose, 0.9% saline, or lactated Ringer's with 5% glucose)
- Before use: Clean IV line with normal saline
Side Effect
- Prolonged QT interval (up to 5%)
- Anxiety
- Dizziness
- Headache
- Weakness
- Constipation
- Diarrhea
- Prutitus
- Hyperkalemia
- First degree atrioventricular block
- Second degree atrioventricular block
- Immune hypersensitivity reaction (very rare)
- Seizure
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Moxifloxacin, Erythromycin, Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole), TCAs
|
May have additive effect on prolonging QT
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.