Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderate to severe acute pain Age: Adult |
Dose: Intramuscular or Subcutaneous Injection – 25-100 mg Frequency: repeated after 4 hours Note: Hepatic impairment: Dose reductions may be necessary. |
|
Indication: Moderate to severe acute pain Age: Adult |
Dose: Slow Intravenous Injection – 25-50 mg Frequency: repeated after 4 hours Note: Hepatic impairment: Dose reductions may be necessary. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderate to severe acute pain Age: 2 months to 12 years |
Dose: Subcutaneous/Intramuscular Injection – 0.5-2 mg/kg Frequency: Repeat dose every 4-6 hours if needed |
|
Indication: Moderate to severe acute pain Age: 12-18 years |
Dose: Subcutaneous/Intramuscular Injection – 20-100 mg Frequency: Repeat dose every 4-6 hours if needed |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: Renal impairment: Dose reductions may be necessary. |
Administration
- Must be diluted before use
- For IV/IM use only
Side Effect
- Hypotension
- fatigue
- drowsiness
- dizziness
- nervousness
- headache
- restlessness
- malaise
- confusion
- depression
- hallucinations
- tremors
- muscle twitches
- increased intracranial pressure
- seizure
- serotonin syndrome
- rash
- urticaria
- nausea
- vomiting
- constipation
- anorexia
- stomach cramps
- xerostomia
- biliary spasm
- paralytic ileus
- sphincter of Oddi spasm
- ureteral spasms
- decreased urination
- pain at Injection site
- weakness
- dyspnoea
- histamine release
- physical and psychological dependence
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aciclovir, Cimetidine, Ritonavir
|
Increased pethidine metabolite levels
|
|
Phenytoin, Barbiturates
|
Reduced analgesic effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at room temperature. Do not freeze and protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.