Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Neuropathic pain, Postherpetic Neuralgia Age: Adult |
Dose: Oral – Initially, 150 mg/day Frequency: in 2 or 3 divided doses Note: may increase to 300 mg/day after 3-7 days. Max: 600 mg/day after a 7-day interval. All doses to be given in 2 or 3 divided doses. |
|
Indication: Diabetic Peripheral Neuropathic Pain Condition: Initial |
Dose: Oral – 50 mg Frequency: every 8 hours Note: by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Haemodialysis |
Dose: – 25-100 mg Frequency: immediately after each 4-hour haemodialysis session |
|
Condition: CrCl 30 to less than 60 ml/min |
Dose: – 75 mg/day Frequency: given in 2 or 3 divided doses Note: Maximum: 300 mg/day |
Administration
- Can be taken with or without food
- Take at same times each day
Side Effect
- Dizziness (8-45%)
- Somnolence (4-36%)
- Peripheral edema (16%)
- Ataxia (1-20%)
- Fatigue (5-11%)
- Xerostomia (1-15%)
- Weight gain (16%)
- Tremor (11%)
- Blurred vision (1-12%)
- Diplopia (12%)
- Asthenia (5%)
- Edema (8%)
- Facial edema (Less than 3%)
- Hypotension (2%)
- Neuropathy (2-9%)
- Pain (5%)
- Disorientation (Less than 2%)
- Constipation (5%)
- Weight gain (4%)
- Accidental injury (4%)
- Abnormal thinking (2%)
- Confusion (Less than 7%)
- Amnesia (Less than 6%)
- Vertigo (1-4%)
- Hypoesthesia (2-3%)
- Euphoria (2%)
- Decreased libido (More than 1%)
- Incoordination (2%)
- Vomiting (1-3%)
- Balance disorder (2-9%)
- Myoclonus (4%)
- Nasopharyngitis pain (1-3%)
- Flu-like syndrome (1-2%)
- Addiction
- Anemia
- Diarrhea
- Gynecomastia and breast enlargement
- Epididymitis
- Esophagitis
- Dysmenorrhea
- Dystonia
- Heart failure
- Hirsutism
- Uveitis
- Neutropenia
- first degree heart block
- hypotension
- hypertension
- pancreatitis
- dysphagia
- oliguria
- rhabdomyolysis
- suicidal thoughts or behavior
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Lorazepam
|
May potentiate effects
|
|
Opiates, Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam)
|
Additive CNS depressant effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Operating Heavy Machinery
|
Causes drowsiness and dizziness
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep in a cool & dry place (below 30° C), protected from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.