Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Complex Partial Seizures |
Dose: Oral – 10-15 mg/kg/day initially; increase by 5-10 mg/kg/day at weekly intervals Note: May increase dose up to 60 mg/kg/day; indicated as monotherapy and adjunctive therapy for complex partial seizures that occur either in isolation or in association with other types of seizures |
|
Indication: Simple and Complex Absence Seizures |
Dose: Oral – 15 mg/kg/day initially Frequency: divided every 6-12 hours Note: Increase by 5-10 mg/kg/day at weekly intervals; may increase dose up to 60 mg/kg/day; also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types that include absence seizures |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Complex Partial Seizures Age: less than 10 years |
Dose: Oral – Safety and efficacy not established Note: Indicated as monotherapy and adjunctive therapy for complex partial seizures that occur either in isolation or in association with other types of seizures |
|
Indication: Complex Partial Seizures Age: 10 years or older |
Dose: Oral – 10-15 mg/kg/day initially Note: Increase by 5-10 mg/kg/day at weekly intervals; may increase dose up to 60 mg/kg/day. Indicated as monotherapy and adjunctive therapy for complex partial seizures that occur either in isolation or in association with other types of seizures. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: No adjustment necessary |
Administration
- Take at same times each day
- Take with food
Side Effect
- Nausea (31%)
- Headache (Less than 31%)
- Increased bleeding time (26-30%)
- Thrombocytopenia (26-30%)
- Tremor (25%)
- Alopecia (Less than 24%)
- Asthenia (16-20%)
- Infection (16-20%)
- Somnolence (16-20%)
- Amblyopia (11-15%)
- Diarrhea (11-15%)
- Diplopia (11-15%)
- Dizziness (11-15%)
- Dyspepsia (11-15%)
- Nystagmus (11-15%)
- Tinnitus (11-15%)
- Vomiting (11-15%)
- Ataxia (Less than 8%)
- Increased appetite (Less than 6%)
- Rash (Less than 6%)
- Abdominal pain (Less than 5%)
- Tremor (Less than 5%)
- Back pain (Less than 5%)
- Mood changes (Less than 5%)
- Anxiety (Less than 5%)
- Confusion (Less than 5%)
- Abnormal gait (Less than 5%)
- Paresthesia (Less than 5%)
- Hallucinations (Less than 5%)
- Catatonia (Less than 5%)
- Dysarthria (Less than 5%)
- Tardive dyskinesia (Less than 5%)
- Vertigo (Less than 5%)
- Irregular menses (Less than 5%)
- Weight gain (4%)
- Anorexia
- Acute pancreatitis (may be life-threatening)
- Hepatic toxicity
- Hyperammonemia
- Weight loss
- Fractures
- Osteoporosis
- Osteopenia
- Decreased bone mineral density
- Cerebral pseudoatrophy
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Bupropion
|
Increased risk of toxicity
|
|
Mefloquine
|
Increased risk of convulsions
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hepatic Dysfunction/Active Liver Disease
|
Can cause severe liver damage
|
|
Porphyria
|
Can trigger acute attacks
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.