Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Local or regional anaesthesia, nerve blocks, epidural and caudal anaesthesia Age: Adult |
Dose: Injection – Per ml prep contains lidocaine HCl 20 mg and epinephrine 5 mcg Note: Dosage depends on several factors such as route, type and extent of surgical procedure, duration of anaesthesia and patient's condition and age. Max dose of lidocaine given with epinephrine: 7 mg/kg and not greater than 500 mg. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Local or regional anaesthesia, nerve blocks, epidural and caudal anaesthesia Age: Child: 3 months-12 years |
Dose: Injection – Per ml preparation contains lidocaine HCl 20 mg and epinephrine 5 mcg Note: Dosage depends on several factors such as route, type and extent of surgical procedure, duration of anaesthesia and patient's condition and age. Maximum dose 3 mg/kg. Ideal body weight should be used in children with high body weight. |
Administration
- Must be administered by healthcare professionals
- Follow specific preparation guidelines
Side Effect
- Severity of adverse effects in CNS and CVS are directly related to blood levels of lidocaine, the effects are more likely to occur after systemic administration rather than infiltration, dizziness, muscle twitching, local anaesthetic of mouth/throat impairs swallowing and increases the risk of aspiration (patients cautioned against eating or drinking for 3-4 hourafter anaesthesia)
- transient effect on auditory system of neonate
- erythema
- pigmentation
- pain
- headache
- palpitations
- local necrosis
- pulmonary oedema
- hyperglycaemia
- bradycardia
- reduced cardiac output
- anxiety
- hypotension
- bradycardia
- nausea and vomiting
- stress reactions such as diaphoresis
- palpitation
- hyperventilation
- generalised pallor and faintness
- Severity of adverse effects in CNS and CVS related to blood levels of lidocaine
- effects more likely to occur after systemic administration rather than infiltration
- CNS toxicity (due to inadvertent IV administration)
- medullary depression with tonic & clonic convulsions
- ventricular fibrillation
- severe hypertension with cerebral haemorrhage and pulmonary oedema
- unconsciousness
- possibly respiratory arrest
- Allergic reactions including anaphylactic symptoms and possibly life threatening asthmatic episodes in susceptible patients may occur due to sodium metabisulphate constituent
- Central nerve blocks may cause CV depression (especially in hypovolaemia)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Suxamethonium
|
Lidocaine prolongs duration of action
|
|
Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam), barbiturates
|
Raise the convulsive threshold to lidocaine
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Tachycardia/hypertension
|
Risk of cardiovascular complications
|
|
Cerebral arteriosclerosis
|
Risk of stroke
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at controlled room temperature, below 25°C
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.