Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: B-Cell Chronic Lymphocytic Leukemia Age: Adult |
Dose: Intravenous infusion – 25 mg/sq.meter Frequency: once daily Duration: 5 days Note: infusion over 30 minutes; up to 30 mg/sq.meter; repeat every 28 days |
|
Indication: B-Cell Chronic Lymphocytic Leukemia Age: Adult |
Dose: Oral – 40 mg/sq.meter Frequency: once daily Duration: 5 days Note: repeat every 28 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Creatinine Clearance 30-70 mL/min |
Dose: Dosage – Reduce by 20% Note: Renal impairment |
|
Condition: Renal impairment Creatinine Clearance less than 30 mL/min |
Dose: Intravenous – Not recommended Note: Renal impairment |
Administration
- For IV use only
- Must be diluted before use
Side Effect
- Fever (69%)
- Objective weakness (65%)
- Anemia (60%)
- Neutropenia (60%)
- Thrombocytopenia (55%)
- Leukopenia (partly therapeutic)
- Infection (44%-not necessarily drug-induced)
- Cough (44%)
- Pain (44%)
- Fatigue (38%)
- N/V (36%)
- Anorexia (34%)
- Malaise (22%)
- Dyspnea (22%)
- Pneumonia (9-22%)
- Edema (19%)
- Myalgia (16%)
- URI (16%)
- UTI (15%)
- Rash (15%)
- Diarrhea (15%)
- Visual disturbances (15%)
- Diaphoresis (13%)
- GI bleeding (13%)
- Paresthesia (12%)
- Abdominal pain (10%)
- Back pain (9%)
- Headache (9%)
- Pharyngitis (9%)
- Stomatitis (9%)
- Flu like syndrome (5-9%)
- Malaise (6%)
- Angina (6%)
- Hearing Loss (2-6%)
- Peripheral edema (7%)
- Alopecia (3%)
- Constipation (1-3%)
- Arrhythmia (3%)
- DVT (1%)
- Myelosuppression
- Fatal autoimmune haemolytic anemia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Pentostatin
|
Co-administration may lead to pulmonary toxicity
|
|
Cytarabine
|
Reduced metabolic activation of fludarabine
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe renal impairment
|
Dangerous for patients with kidney problems (CrCl <30 mL/min)
|
|
Decompensated hemolytic anemia
|
Can worsen blood condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Refrigerate at 2-8° C
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.