Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute uncomplicated urinary tract infections Age: Adult |
Dose: Oral – 50-100 mg Frequency: four times daily Duration: 7 days or for 3 days after obtaining sterile urine |
|
Indication: Acute uncomplicated urinary tract infections Age: Adult Condition: SR preparation |
Dose: Oral – 100 mg Frequency: twice daily Duration: 7 days or for 3 days after obtaining sterile urine |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Urinary Tract Infection Age: greater than 1 month |
Dose: by mouth (oral) – 5-7 mg/kg/day Frequency: divided every 6 hours Duration: for 7 days |
|
Indication: UTI prophylaxis Age: greater than 1 month |
Dose: by mouth (oral) – 1-2 mg/kg Frequency: at bedtime or 2 divided doses |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: creatinine clearance less than 60 mL/min |
Dose: Not specified Note: Loses effectiveness in patients with creatinine clearance less than 60 mL/min due to inadequate urine concentration |
|
Age: Geriatric Condition: Decreased renal function |
Dose: Not specified Note: Monitor renal function; renally excreted; decreased renal function more likely in elderly |
Administration
- Take with food or milk
- Take at same times each day
Side Effect
- Nausea
- vomiting
- anorexia
- abdominal pain
- diarrhoea
- headache
- drowsiness
- vertigo
- dizziness
- nystagmus
- benign intracranial hypertension
- rash
- urticaria
- pruritus
- fever
- sialadenitis
- angioedema
- erythema multiforme
- exfoliative dermatitis
- pancreatitis
- lupus-like syndrome
- myalgia
- arthralgia
- acute pulmonary sensitivity reactions
- megaloblastic anaemia
- leucopenia
- granulocytopenia or agranulocytosis
- thrombocytopenia
- aplastic anaemia
- haemolytic anaemia (in G6PD-deficient patients)
- transient alopecia
- brownish discolouration of urine
- Peripheral polyneuropathy
- hepatotoxicity
- anaphylaxis
- Stevens-Johnson syndrome
- interstitial pneumonitis
- pulmonary fibrosis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Probenecid, Sulfinpyrazone
|
Reduced excretion
|
|
Magnesium trisilicate
|
Absorption reduced
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Impairment
|
Drug accumulation can cause toxicity
|
|
Anuria
|
Medication will be ineffective
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.