Medicine Overview

Indication

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Adult Dose

Clinical InformationAdministration Information
Indication: Adjunct in partial seizures
Age: Adult
Dose: Oral – Initially, 50 mg daily
Frequency: twice daily
Note: Increase to 100 mg daily after 1 week. Thereafter, may further increase dose at weekly intervals in increments of up to 100 mg. Usual maintenance dose: 300-500 mg daily, some patients may respond to lower doses.
Indication: Monotherapy for partial seizures with or without secondary generalisation
Age: Adult
Condition: Newly diagnosed epilepsy
Dose: Oral – Initially, 100 mg
Frequency: once daily
Note: Increase to 200 mg once daily after 2 weeks. May further increase by increments of 100 mg at intervals of at least 2 weeks. Usual maintenance dose: 300 mg once daily, up to 500 mg daily.

Child Dose

Clinical InformationAdministration Information
Indication: Adjunct in partial seizures
Age: greater than 6 years
Condition: Initial dose
Dose: Oral – 1 mg/kg
Frequency: once daily
Duration: for 1 week
Note: may increase by increments of 1 mg/kg at weekly interval
Indication: Adjunct in partial seizures
Age: greater than 6 years
Condition: Usual maintenance dose
Dose: Oral – 6-8 mg/kg
Frequency: once daily

Renal Dose

Clinical InformationAdministration Information
Condition: Renal impairment: Glomerular Filtration Rate greater than or equal to 50 mL/minute
Dose: Not specified
Note: Slower dosage titration may be needed.
Condition: Renal impairment: Glomerular Filtration Rate less than 50 mL/minute
Dose: Not specified
Note: Not recommended.
Administration
  • Can be taken with or without food
  • Take at regular intervals
Side Effect

Drug Interaction

Drug NameRisk Factors
Phenytoin, phenobarbital, carbamazepine
Reduced plasma concentration
Carbonic Anhydrase Inhibitors (Acetazolamide, Dorzolamide, Brinzolamide) (e.g. acetazolamide)
Increased risk of metabolic acidosis

Disease Interaction

Disease NameRisk Factors
No specific contraindications listed
Monitor for general drug reactions

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage

Details coming soon

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.