Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Amyotrophic lateral sclerosis
Age: Adult
Dose: Oral – 50 mg
Frequency: twice daily
Note: Discontinue if alanine aminotransferase levels increase to 5 times the upper limit of normal.
Indication: Amyotrophic lateral sclerosis
Age: Adult
Condition: Hepatic impairment Mild or moderate (Child-Pugh A or B)
Dose: Oral – 50 mg
Frequency: twice daily
Note: Patients had increases in area under the curve; thus, may be at increased risk of adverse reactions.

Child Dose

Clinical InformationAdministration Information
Age: Child
Dose: Tablet – No approved pediatric dosage available
Note: No approved pediatric dosage available
Administration
  • Take on empty stomach
  • Take 1 hour before or 2 hours after meals
Side Effect

Drug Interaction

Drug NameRisk Factors
CYP1A2 inhibitors (e.g. caffeine, ciprofloxacin, oral contraceptives)
Decreased rate of elimination
CYP1A2 inducers (e.g. rifampicin, omeprazole)
Increased rate of elimination

Disease Interaction

Disease NameRisk Factors
Severe liver impairment
Risk of liver toxicity

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at controlled room temperature, 20°C to 25°C, and protect from bright light.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.