Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Passive immunisation against hepatitis B infection Age: Adult |
Dose: Intramuscular – 500 IU Frequency: single dose Note: Given preferably within 48 hours of exposure and not greater than 1 week after exposure. Contents of hepatitis B immunoglobulin may vary between countries and between manufacturers. Caution should be taken in interpreting dosage recommendations which are not given in terms of IU. |
|
Indication: Prophylaxis of hepatitis B recurrence after liver transplantation Age: Adult |
Dose: Intravenous – 20,000 IU/dose Frequency: 1 dose Duration: with liver transplant Note: Initially given. Contents of hepatitis B immunoglobulin may vary between countries and between manufacturers. Caution should be taken in interpreting dosage recommendations which are not given in terms of IU. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Passive immunisation against hepatitis B infection Age: less than 5 years |
Dose: Intramuscular – 200 IU Frequency: single dose Note: preferably within 48 hours of exposure and not greater than 1 week after exposure; contents of hepatitis B immunoglobulin may vary between countries and between manufacturers |
|
Indication: Passive immunisation against hepatitis B infection Age: 5-9 years |
Dose: Intramuscular – 300 IU Frequency: single dose Note: preferably within 48 hours of exposure and not greater than 1 week after exposure; contents of hepatitis B immunoglobulin may vary between countries and between manufacturers |
Administration
- For IM use only
- Must be given by healthcare professional
Side Effect
- Fainting
- headache
- lightheadedness
- malaise
- angioedema
- bruising
- urticaria
- nausea
- vomiting
- increased AST and alkaline phosphatase
- Ache
- pain
- erythema and/or tenderness at Injection site
- Anaphylaxis
- cold/flu-like syndrome
- arthralgia
- joint stiffness and myalgia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Live vaccines
|
May interfere with immune response
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Gamma Globulin Allergy
|
Risk of life-threatening reaction
|
|
Thrombocytopenia
|
Risk with intramuscular injection
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a refrigerator (2-8°C). Keep in the outer carton in order to protect from light. Keep out of the reach and sight of children
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.