Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute bacterial sinusitis Age: Adult |
Dose: Intravenous infusion – 400 mg Frequency: once daily Duration: 10 days Note: Infused over 60 minutes. |
|
Indication: Acute bacterial exacerbation of chronic bronchitis Age: Adult |
Dose: Intravenous infusion – 400 mg Frequency: once daily Duration: 5 days Note: Infused over 60 minutes. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: Not established Note: Safety and efficacy not established |
Administration
- For IV infusion only
- Infuse over 1 hour
Side Effect
- Nausea (7%)
- Diarrhea (6%)
- Dizziness (3%)
- Decreased amylase (2%)
- Decreased basophils
- eosinophils
- hemoglobin
- prothrombin time
- red blood cells
- neutrophils (2%)
- Decreased serum glucose (2%)
- Increased serum chloride (2%)
- Increased serum ionized calcium (2%)
- Immune hypersensitivity reaction (0.1-2%)
- Prolonged QT interval (0.1-2%)
- Acute renal failure
- Agranulocytosis
- Anaphylactoid reaction
- Aplastic anemia
- Extrinsic allergic alveolitis
- Hemolytic anemia
- Hepatic failure
- Hepatic necrosis
- Hepatitis
- Pancytopenia
- Seizure
- Serum sickness due to drug
- Stevens-Johnson syndrome
- Tendon rupture
- tendinitis
- Thrombocytopenia
- Torsades de pointes
- Toxic epidermal necrolysis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Erythromycin, TCAs, Antipsychotic agents
|
Additive effect on QT interval prolongation
|
|
Al- or Mg-containing antacids, Fe or Zn preparations
|
Decreased absorption and bioavailability
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Known Hypersensitivity
|
Risk of severe allergic reactions
|
|
Known QT Interval Prolongation
|
Risk of heart rhythm problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 25°C and protect from light. Avoid extreme heat and freezing. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.