Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is an oral anti-diabetic medication used to control Type 2 diabetes. It belongs to the biguanide class. It lowers blood sugar levels by reducing glucose production in the liver and increasing insulin sensitivity in muscle and fat cells. It works by activating AMP-activated protein kinase (AMPK).

Question 2

When and how should this medicine be taken?

Accepted Answer

• Take with food • Take with meals to reduce stomach upset • Swallow whole with water • Take at the same time each day

Question 3

When should this medicine not be used?

Accepted Answer

• In severe kidney disease • In acute metabolic acidosis • In severe sepsis

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• Monitor kidney function regularly • May lower vitamin B12 levels - get checked periodically • Risk of low blood sugar when used with insulin • Avoid in severe kidney disease

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Generally considered safe during pregnancy • May be used to treat gestational diabetes • Consult healthcare provider for proper dosing

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• Monitor kidney function regularly • May lower vitamin B12 levels - get checked periodically • Risk of low blood sugar when used with insulin • Avoid in severe kidney disease

Question 7

Is this medicine suitable for children and elderly?

Accepted Answer

• Monitor children's growth and puberty • Particular caution needed for ages 10-12 years • Elderly need regular kidney function assessment

Question 8

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For twice-daily dosing: If more than 6 hours until your next dose, take the missed dose. • For once-daily dosing: If you remember on the same day, take the dose. • Take your next dose at the regular time. • If you miss multiple doses, contact your doctor.

Question 9

What should be done in case of an overdose?

Accepted Answer

• Symptoms: Lactic acidosis. • Treatment: Hemodialysis, monitor acid-base balance.

Question 10

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Nausea, diarrhea, vomiting, stomach pain, loss of appetite, metallic taste, weakness ** • What to do: Take with meals; Start with low dose; Stay hydrated; Monitor blood sugar; Report severe abdominal pain; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 11

What is Comet 850mg used for?

Accepted Answer

Comet 850mg (Metformin Hydrochloride) is a pharmaceutical medicine manufactured by Square Pharmaceuticals Ltd. in Bangladesh. It is primarily prescribed for Diabetes Mellitus Type 2, Polycystic Ovarian Syndrome (PCOS).

Question 12

What is the active generic component of Comet?

Accepted Answer

The active ingredient in Comet is Metformin Hydrochloride, belonging to the Biguanides drug class.

Question 13

What is the retail price of Comet 850mg in Bangladesh?

Accepted Answer

The official retail price of Comet 850mg (Tablet) is ৳6.02 in Bangladesh (prices may vary slightly by pack size and authorized pharmacy).

Question 14

What is the recommended dosage for Comet?

Accepted Answer

Standard adult dosage: Oral preparation – 500 mg (twice daily or three times daily). Pediatric dosage: Oral – 500 mg (1-2 times daily). Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 15

Is Comet safe during pregnancy and breastfeeding?

Accepted Answer

Comet is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 16

What are the common side effects of Comet?

Accepted Answer

Anorexia; nausea; vomiting; diarrhoea; weight loss; flatulence; occasional metallic taste; weakness; hypoglycaemia; rash; malabsorption of vit B12; Chest discomfort; flushing; palpitation; chills; headache; lightheadedne

Clinical Information	Administration Information
Indication: Type 2 diabetes mellitus Age: Adult Condition: Conventional preparation	Dose: Oral preparation – 500 mg Frequency: twice daily or three times daily Note: Initially 500 mg twice daily or three times daily, or 850 mg 1-2 times daily, may increase gradually to 2000 mg daily at intervals of at least 1 week. Maximum daily dose of 2550 mg per day.
Indication: Type 2 diabetes mellitus Age: Adult Condition: Modified-release preparation	Dose: Oral preparation – 500 mg Frequency: once daily Note: Initially 500 mg once daily, may increase in increments of 500 mg at intervals of at least 1 week to maximum 2000 mg once daily at night. If glycaemic control is not sufficient, dose may be divided to 1000 mg twice daily. Not to exceed 2000 mg/day.

Clinical Information	Administration Information
Indication: Type 2 diabetes mellitus Age: greater than 10 yr	Dose: Oral – 500 mg Frequency: 1-2 times daily Note: initially, may increase gradually to maximum 2000 mg daily in 2 or 3 divided doses at intervals of at least 1 week
Indication: Type 2 diabetes mellitus Age: greater than 10 yr	Dose: Oral – 850 mg Frequency: once daily Note: initially, may increase gradually to maximum 2000 mg daily in 2 or 3 divided doses at intervals of at least 1 week

Clinical Information	Administration Information
Age: Elderly Condition: Renal impairment	Dose: Tablet – Dosage not specified Note: Monitor estimated glomerular filtration rate at least annually or more often for those at risk for renal impairment
Condition: Renal impairment with estimated glomerular filtration rate less than 30 mL/min/1.73 m2	Dose: Tablet – Dosage not specified Note: Contraindicated; discontinue the drug if estimated glomerular filtration rate falls below 30 mL/min/1.73 m2 while taking metformin

Disease Name	Risk Factors
Acute/Chronic Metabolic Acidosis	Can worsen acid-base balance
Diabetic Ketoacidosis	Increases risk of severe acidosis

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

Is this medicine suitable for children and elderly?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Renal Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources