Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: mild-to-moderate dementia of the Alzheimer's type Age: Adult Condition: Alzheimer Dementia |
Dose: Oral – 1.5 mg Frequency: every 12 hours Note: Initial dose. Increase by 1.5 mg per dose every 2 weeks; not to exceed 6 mg by mouth every 12 hours. Maintenance: 3-6 mg by mouth every 12 hours (higher end may be more beneficial). |
|
Indication: mild, moderate, and severe dementia of the Alzheimer's type Age: Adult Condition: Alzheimer Dementia |
Dose: Transdermal patch – 4.6 mg Frequency: every 24 hours Note: Initial dose. Replace with new patch every 24 hours. May increase dose to 9.5 mg every 24 hours after a minimum 4 weeks if well tolerated; after an additional 4 weeks, may further increase to 13.3 mg patch if needed. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Transdermal – No dosage adjustment required Note: Renal impairment: No dosage adjustment required |
Administration
- Take with food
- Take morning and evening
Side Effect
- Nausea (PO 47%
- patch 21%)
- Vomiting (PO 31%
- patch 6-19%)
- Dizziness (PO 21%
- patch 2-7%)
- Diarrhea (PO 19%
- patch 6-10%)
- Headache (PO 17%
- patch 3-4%)
- Anorexia (PO 17%
- patch 3-9%)
- Abdominal pain (PO 13%
- patch 2-4%)
- Decreased weight (3-8%)
- Insomnia (PO 9%
- patch 1-4%)
- Anxiety (PO 5%
- patch 3%)
- Asthenia (PO 6%
- patch 2-3%)
- Vertigo (2%)
- Fatigue (2%)
- Serious GI reactions such as anorexia
- vomiting and weight loss
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cholinomimetic drugs
|
Not to be used together as might interfere with anticholinergic medications
|
|
Succinylcholine-type Muscle Relaxants (Baclofen, Cyclobenzaprine, Tizanidine, Dantrolene)
|
May exaggerate effects during anesthesia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Hepatic Impairment
|
Risk of liver function deterioration
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.