Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 1 Diabetes Mellitus Age: Adults and children |
Dose: Subcutaneous – 0.2-0.6 unit/kg/day Frequency: in divided doses Note: Conservative doses of 0.2-0.4 unit/kg/day often recommended to reduce risk of hypoglycemia. Total maintenance daily insulin requirement may vary; it is usually between 0.5 and 1 unit/kg/day. Dosage must be individualized; blood and urine glucose monitoring is essential. |
|
Indication: Type 1 Diabetes Mellitus Age: Adults and children Condition: Nonobese |
Dose: Subcutaneous – 0.4-0.6 unit/kg/day Note: Total maintenance daily insulin requirement. Dosage must be individualized; blood and urine glucose monitoring is essential. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 1 Diabetes Mellitus Age: Adults and children greater than 2 years Condition: During growth spurts |
Dose: Subcutaneous – 0.8-1.2 units/kg/day Note: Improvement of glycemic control |
|
Indication: Type 1 Diabetes Mellitus Age: Adolescents |
Dose: Subcutaneous – less than 1.2 units/kg/day Note: Improvement of glycemic control |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: Dose adjustments may be needed |
Administration
- Inject 5-10 minutes before meals
- Rotate injection sites
Side Effect
- Allergic reactions
- Injection site reaction
- lipodystrophy
- pruritus
- rash
- lipoatrophy
- hypokalaemia
- blurred vision
- Hypoglycaemia
- insulin resistance
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Oral antidiabetic agents, ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), disopyramide, fibrates, fluoxetine, MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide), propoxyphene, salicylates, somatostatin analog (e.g., octreotide), Sulfonamide Antibiotics (Sulfamethoxazole, Sulfisoxazole, Sulfadiazine)
|
Effects may be increased
|
|
Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone), niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium
|
Effects may be decreased
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypoglycemia
|
Risk of dangerously low blood sugar
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 2°C to 8°C in a refrigerator. Do not freeze. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.