Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute Migraine Age: Adult Condition: Normal or Mild to Moderate Hepatic Impairment (Child-Pugh A or B) |
Dose: Tablet – 50 mg, 100 mg, or 200 mg Frequency: as needed Note: by mouth. Not to exceed more than 1 dose/24 hours. Do not take unless patient can wait at least 8 hours between dosing and driving or operating machinery. Second dose has not been shown to be effective for the same migraine attack. The safety of treating an average of greater than 4 migraine attacks/30 days has not been established. Hepatic impairment Mild or moderate (Child-Pugh A or B): No dosage adjustment needed. |
|
Indication: Acute Migraine Age: Adult Condition: Severe Hepatic Impairment (Child-Pugh C) |
Dose: Tablet Note: Not recommended. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: n/a – n/a Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: No dosage adjustment needed Note: No dosage adjustment needed for any degree of renal impairment |
Administration
- Can take with or without food
- Take as soon as migraine begins
Side Effect
- Dizziness (9-17%)
- Paresthesia (3-9%)
- Sedation (6-7%)
- Fatigue (4-6%)
- Nausea and/or vomiting (3-4%)
- Muscle weakness (1-2%)
- Vertigo
- Incoordination
- Lethargy
- Visual impairment
- Feeling abnormal
- Palpitations
- Anxiety
- Tremor
- Restlessness
- Sleep abnormalities (eg sleep disturbance, abnormal dreams)
- Muscle spasm
- Limb discomfort
- Cognitive changes
- Confusion
- Euphoric mood
- Chest discomfort
- Speech abnormalities
- Dyspnea
- Hallucinations
- Hypersensitivity (eg angioedema, rash, photosensitivity reaction)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CNS depressants
|
Use with caution - sedation risk
|
|
Serotonin-increasing drugs
|
Risk of serotonin syndrome
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.