Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Intravenous Candida Infections Condition: Day 1 loading dose |
Dose: Intravenous – 70 mg Frequency: once daily Duration: as a single dose Note: Infused over 1 hour. Includes candidemia and other Candida infections including intra-abdominal abscesses, peritonitis, and pleural space infections. |
|
Indication: Intravenous Candida Infections Condition: Maintenance |
Dose: Intravenous – 50 mg Frequency: once daily Duration: for at least 14 days after last positive culture Note: Infused over 1 hour. Patients who remain persistently neutropenic may warrant longer course of therapy pending resolution of neutropenia. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Candida Infections Age: less than 3 months Condition: limited data suggest an off-label dose |
Dose: Intravenous – Not applicable Frequency: once daily Note: Safety and efficacy not established |
|
Indication: Candida Infections Age: greater than 3 months Condition: Day 1 loading dose |
Dose: Intravenous – 70 mg/m2 Duration: 1 day Note: Infused over 1 hour |
Administration
- For IV infusion only
- Infuse over 1 hour
Side Effect
- Infused vein complications/ phlebitis (20-35%)
- Fever (6-30%)
- Diarrhea (6-27%)
- Shivering (9-23%)
- Rash (4-23%)
- Incr serum alk phos (9-22%)
- Hypotension (3-20%)
- Respiratory failure (2-20%)
- Incr transaminases (2-18%)
- Septic shock (11% to 14% )
- Pleural effusion (9%)
- Respiratory distress (up to 8%)
- Abdominal pain
- Nausea
- Vomiting
- Anemia
- Decreased Hgb
- Neutropenia
- Chills
- Hypokalemia
- Dizziness
- Erythema
- Facial edema
- flushing
- Hematuria
- Hyperbilirubinemia
- Increased serum creatinineeatinine
- Induration
- Myalgia
- Pain
- Paresthesia
- Pruritus
- Sepsis
- Tachycardia
- Erythema multiforme
- Stevens-Johnson syndrome
- ancreatitis
- Hepatic necrosis
- Liver failure
- Anaphylaxis
- Nephrotoxicity
- Renal impairment
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampicin and other CYP enzyme inducers
|
Reduced plasma concentration
|
|
Ciclosporin
|
May increase hepatic enzymes
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Risk of allergic reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.