Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Amyotrophic lateral sclerosis Age: Adult |
Dose: Oral – 50 mg Frequency: twice daily Note: Discontinue if alanine aminotransferase levels increase to 5 times the upper limit of normal. |
|
Indication: Amyotrophic lateral sclerosis Age: Adult Condition: Hepatic impairment Mild or moderate (Child-Pugh A or B) |
Dose: Oral – 50 mg Frequency: twice daily Note: Patients had increases in area under the curve; thus, may be at increased risk of adverse reactions. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Take on empty stomach
- Take 1 hour before or 2 hours after meals
Side Effect
- Oral hypoesthesia (29%)
- Asthenia (19%)
- Nausea (16%)
- Decreased lung function (10%)
- Hypertension (5%)
- Abdominal pain (5%)
- Vomiting (4%)
- Arthralgia (4%)
- Dizziness (4%)
- Dry mouth (4%)
- Insomnia (4%)
- Pruritus (4%)
- Tachycardia (3%)
- Flatulence (3%)
- Increased cough (3%)
- Peripheral edema (3%)
- Urinary Tract Infection (UTI) (3%)
- Circumoral paresthesia (2%)
- Somnolence (2%)
- Vertigo (2%)
- Eczema (2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP1A2 inhibitors (e.g. caffeine, ciprofloxacin, oral contraceptives)
|
Decreased rate of elimination
|
|
CYP1A2 inducers (e.g. rifampicin, omeprazole)
|
Increased rate of elimination
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe liver impairment
|
Risk of liver toxicity
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at controlled room temperature, 20°C to 25°C, and protect from bright light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.