Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: Adult |
Dose: Immediate-release tablet – 1 tablet Frequency: twice daily Note: Take with meals, with gradual dose escalation to reduce the gastrointestinal adverse effects due to metformin. Maximum: Empagliflozin 25 mg and metformin 2,000 mg daily. |
|
Indication: Type 2 diabetes mellitus Age: Adult |
Dose: Extended-release tablet – 1 tablet Frequency: once daily Note: Take with a meal in the morning, with gradual dose escalation to reduce the gastrointestinal adverse effects due to metformin. Maximum: Empagliflozin 25 mg and metformin 2,000 mg daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: 10 years and older Condition: New to both components |
Dose: Oral – 5 mg empagliflozin/500 mg metformin Frequency: Twice daily Note: Dose individualized based on current regimen; Route: Oral; Maximum Dose: Empagliflozin 25 mg and metformin 2,000 mg per day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dose: Note: Contraindicated |
Administration
- Take with meals
- Take at regular intervals
Side Effect
- Urinary Tract Infection (UTI) (7.6-9.3%)
- Decreased vitamin B12 levels (7%)
- Increased LDL-C (4.6-6.5%)
- Female genital mycotic infections (5.4-6.4%)
- Dyslipidemia (2.9-3.9%)
- Increased urination (3.2-3.4%)
- Male genital mycotic infections (1.6-3.1%)
- Nausea (1.1-2.3%)
- Hypoglycemia with monotherapy (1.4-1.8%)
- Volume depletion
- Impaired renal function
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Thiazides and loop diuretics (Furosemide, Bumetanide, Ethacrynic acid, Torsemide)
|
May potentiate diuretic effect and increased risk of hypotension
|
|
UGT enzyme inhibitor (e.g. probenecid)
|
Increased plasma concentration of empagliflozin
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Diabetic Pre-Coma
|
Risk of metabolic crisis
|
|
Acute Metabolic Acidosis
|
Risk of life-threatening acidosis
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.