Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Heart Failure
Condition: Initial
Dose: Oral – 5 mg
Frequency: twice daily
Note: with meals. After 2 weeks, assess patient and adjust dose to achieve a resting heart rate of 50-60 beats per minute. Thereafter, adjust dose as needed based on resting heart rate and tolerability; not to exceed 7.5 mg twice daily.
Indication: Heart Failure
Condition: Dose adjustment heart rate greater than 60 beats per minute
Dose: Oral – 2.5 mg
Frequency: twice daily
Note: Increase dose by 2.5 mg (given twice daily) up to a maximum dose of 7.5 mg twice daily.

Child Dose

Clinical InformationAdministration Information
Age: Child
Dose: Safety and efficacy not established
Note: Not established

Renal Dose

Clinical InformationAdministration Information
Condition: Renal impairment: Creatinine Clearance less than 15 ml/min
Dose: Not specified
Note: Use with caution.
Administration
  • Take with food
  • Regular timing
Side Effect

Drug Interaction

Drug NameRisk Factors
Quinidine, Disopyramide, Bepridil, Sotalol, Ibutilide, Amiodarone, Pimozide, Ziprasidone, Sertinole, Mefloquine, Halofantrine, Pentamide, Cisapride, Erythromycin IV
Concomitant use not recommended, may enhance QT prolongation
CYP3A4 inhibitors
May increase concentrations

Disease Interaction

Disease NameRisk Factors
Resting heart rate <60 beats/min
Risk of dangerous bradycardia
Cardiogenic shock
Can worsen shock state

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.