Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Schizophrenia |
Dose: by mouth – 40 mg Frequency: once daily initially Note: may increase to 80 mg/day if needed; not to exceed 160 mg/day |
|
Indication: Bipolar Depression Condition: major depressive episodes associated with bipolar I disorder; may be used as either monotherapy or adjunctive therapy with lithium or valproate |
Dose: by mouth – 20 mg Frequency: once daily initially Note: may increase dose if needed, not to exceed 120 mg/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Dose: Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: creatinine clearance 50 mL/minute or greater Condition: Renal impairment |
Dose: Dosage Form – Dosage adjustment not required Note: Dosage adjustment not required |
|
Indication: creatinine clearance less than 50 mL/minute Condition: Renal impairment |
Dose: Dosage Form – 20 mg/day initially Frequency: once daily Note: not to exceed 80 mg/day |
Administration
- Take with food
- Take at least 350 calories
Side Effect
- Somnolence
- dose related (22%)
- Akathisia
- dose related (15%)
- Fasting glucose increased (10-14%)
- Nausea (12%)
- Parkinsonism (11%)
- Vomiting (8%)
- Dyspepsia (8%)
- Anxiety (8%)
- Agitation (6%)
- Anxiety (6%)
- Dystonia (5%)
- Dizziness (5%)
- Fatigue (4%)
- Back pain (4%)
- Restlessness (3%)
- Salivary hypersecretion (2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
No interactions listed
|
-
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Drug Hypersensitivity
|
Risk of allergic reaction
|
|
Dementia-Related Psychosis
|
Increased mortality risk
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Protect from light and moisture, store below 30° C. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.