Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Huntington Disease Age: Adult |
Dose: Oral – 12.5 mg Frequency: once daily initially; after 1 week, increase to 12.5 mg twice daily Note: Individualize and slowly titrate dosage over several weeks to identify a dose that reduces chorea and is well tolerated. Total daily dose up to 50 mg/day. |
|
Indication: Huntington Disease Age: Adult Condition: Maintenance dose 37.5 to 50 mg/day |
Dose: Oral – 37.5 to 50 mg Frequency: in divided doses three times daily Note: Titrate slowly by weekly intervals of 12.5 mg/day to identify dose that reduces chorea and is tolerated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Dosage Form – No approved dosage available Note: No approved pediatric dosage available |
Administration
- Can take with or without food
- Take at regular times
Side Effect
- Sedation/somnolence (31%)
- Fatigue (22%)
- Insomnia (22%)
- Depression (19%)
- Akathisia (19%)
- Extrapyramidal event (15%)
- Anxiety (15%)
- Nausea (13%)
- Irritability (9%)
- Bruising (6%)
- Vomiting (6%)
- Decreased appetite (4%)
- Dysuria (4%)
- Obsessive reaction (4%)
- Imbalance (9%)
- Parkinsonism/bradykinesia (9%)
- Dizziness (4%)
- Dysarthria (4%)
- Unsteady gait (4%)
- Headache (4%)
- QTc prolongation
- Neuroleptic malignant syndrome
- Orthostatic Hypotension
- Restlessness and agitation
- Dysphagia
- Depression and suicidality
- Neuroleptic malignant syndrome (NMS)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Monoamine oxidase inhibitors
|
Should not be given within 14 days of discontinuation
|
|
Reserpine
|
Blocks action
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hepatic Impairment
|
Risk of drug toxicity
|
|
Active Suicidal Thoughts
|
Risk of suicide attempt
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.