Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hyperlipidaemia, Bile acid-induced diarrhoea Age: Adult |
Dose: Oral – 4 g Frequency: once every 12-24 hours Note: Increase gradually over greater than 1 month intervals. |
|
Indication: Hyperlipidaemia, Bile acid-induced diarrhoea Age: Adult Condition: Maintenance |
Dose: Oral – 8-16 g/day Frequency: divided every 12 hours Note: By mouth. Not to exceed 24 g/day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hyperlipidaemia, Bile acid-induced diarrhoea Age: greater than 6 years |
Dose: Oral – 240 mg/kg/day Frequency: divided every 8-12 hours Note: generally not to exceed 8 g/day |
|
Indication: Pruritus associated with partial biliary obstruction or primary biliary cirrhosis Age: greater than 6 years |
Dose: Oral – 240 mg/kg daily Frequency: in divided doses |
Administration
- Mix with water or juice
- Don't take dry powder
Side Effect
- Constipation
- faecal impaction
- haemorrhoids
- abdominal discomfort or pain
- heartburn
- flatulence
- nausea
- vomiting
- diarrhoea
- increased bleeding tendency (chronic use)
- osteoporosis
- steatorrhoea (high doses)
- skin rashes
- pruritus of the tongue
- skin and perianal region
- hyperchloraemic acidosis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Folic acid, Thiazide diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone), many other drugs*
|
Delayed or reduced absorption
|
|
Fat-soluble vitamins
|
May prevent absorption
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Complete Biliary Obstruction
|
Risk of ineffective treatment
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.