Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Uncomplicated skin and skin structure infections Age: Adult |
Dose: Oral – 400 mg Frequency: every 12 hours Duration: for 10-14 days |
|
Indication: Vancomycin-resistant Enterococcus faecium Age: Adult |
Dose: Oral – 600 mg Frequency: every 12 hours Duration: for 14-28 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Pneumonia, complicated skin infections, vancomycin resistant enterococci Age: Birth–11 years |
Dose: Oral – 30 mg/kg/day Frequency: every 8 hours |
|
Indication: Pneumonia, complicated skin infections, vancomycin resistant enterococci Age: greater than 11 years |
Dose: Oral – 1,200 mg/day Frequency: every 12 hours |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Renal Dose – No dosage adjustment needed Note: Renal impairment: No dosage adjustment needed. |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Diarrhea (7.8-10.8%)
- Headache (5.7-8.8%)
- Diarrhea (8.2-8.3%)
- Nausea (5.1-6.6%)
- Vomiting (2-4.3%)
- Dizziness (1.8-2.6%)
- Rash (1.1-2.3%)
- Vaginal moniliasis (1.1-1.8%)
- Taste alteration (1-1.8%)
- Oral moniliasis (0.5-1.7%)
- Abnormal LFTs (0.4-1.6%)
- Fungal infection (0.3-1.5%)
- Localized abdominal pain (1.2-1.3%)
- Tongue discoloration (0.3-1.3%)
- Generalized abdominal pain (0.9-1.2%)
- Vomiting (2.9-9.4%)
- Headache (0.9-6.5%)
- Anemia (5.6%)
- Thrombocytopenia (4.7%)
- Nausea (1.9-3.7%)
- Generalized abdominal pain (0.9-2.4%)
- Localized abdominal pain (0.5-2.4%)
- Loose stools (1.6-2.3%)
- Eosinophilia (0.4-1.9%)
- Pruritus
- other than application site (0.8-1.4%)
- Vertigo (1.2%)
- Lactic acidosis
- Myelosuppression
- Peripheral neuropathy
- Disorder of optic nerve
- Serotonin syndrome
- Reversible myelosuppression including anaemia
- leukopenia
- pancytopenia and thrombocytopenia (particularly if using More than 10-14 days)
- transient ischaemic attacks
- renal failure
- Stevens-Johnson syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampicin, Phenytoin
|
May reduce serum levels
|
|
Insulin, Oral Antidiabetics (Metformin, Glibenclamide, Glimepiride, Sitagliptin, Pioglitazone, Rosiglitazone, Empagliflozin)
|
May cause hypoglycaemia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity to Linezolid
|
Risk of severe allergic reaction
|
|
Uncontrolled hypertension
|
Risk of blood pressure crisis
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Linezolid formulations should be stored at room temperature (15°C-30°C), away from light and moisture. All medicines should be kept away from children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.