Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Heart Failure Risk Reduction Age: Adults Condition: Symptomatic chronic heart failure and ejection fraction less than 45%, following hospitalization for heart failure or need for outpatient intravenous diuretics |
Dose: by mouth – 2.5 mg Frequency: once daily Note: Initial dose |
|
Indication: Heart Failure Risk Reduction Age: Adults Condition: Symptomatic chronic heart failure and ejection fraction less than 45%, following hospitalization for heart failure or need for outpatient intravenous diuretics |
Dose: by mouth – 10 mg Frequency: once daily Note: Maintenance dose; double dose every 2 weeks as tolerated to target dose |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Form – No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: eGFR greater than 15 mL/min/1.73m2 and not on dialysis |
Dose: Not specified – Not specified Note: No dosage adjustment necessary |
|
Age: Adult Condition: eGFR less than 15 mL/min/1.73m2 or on dialysis |
Dose: Not specified – Not specified Note: Not studied |
Administration
- Should be taken with food
- Take at same time each day
Side Effect
- Hypotension (16%)
- placebo (15%)
- Anemia (10%)
- placebo (7%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Other sGC Stimulators (Soluble Guanylate Cyclase Stimulators)
|
Coadministration is contraindicated
|
|
PDE-5 inhibitors
|
Coadministration not recommended due to potential for hypotension
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.