Indication
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Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prevent pregnancy Age: Females of reproductive potential |
Dose: Oral active tablet – 3 mg drospirenone/14.2 mg estetrol Frequency: once daily Duration: Days 1-24 Note: by mouth |
|
Indication: Prevent pregnancy Age: Females of reproductive potential |
Dose: Oral inert tablet – 1 tablet Frequency: once daily Duration: Days 25-28 Note: by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Contraception Age: Females of reproductive potential after menarche |
Dose: Tablet – One pink active tablet (3 mg drospirenone and 14.2 mg estetrol) Frequency: Once daily Duration: daily for 24 days Note: followed by one white inactive tablet daily for 4 days; Route: Oral (by mouth) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not mentioned – Not mentioned Note: Contraindicated for all severities of renal impairment |
|
Condition: Renal impairment |
Dose: Not mentioned – Not mentioned Note: Serum DRSP concentrations were approximately 37 higher than control group |
Administration
Administer one tablet orally at the same time every day, with or without food, for 28 consecutive days. Each cycle consists of 24 active tablets followed by 4 inert tablets. Start on the first day of menses or use non-hormonal backup contraception for the first seven days if starting later. In the event of vomiting or severe diarrhea within four hours of ingestion, an additional active tablet should be taken. This combination is intended for females of reproductive potential and is not recommended for individuals with a body mass index of 30 kg/m² or higher due to potentially decreased efficacy. Check serum potassium during the first cycle in patients taking chronic medications that may increase potassium levels. Monitor for signs of thromboembolism and hepatic impairment.
Side Effect
- Bleeding irregularities (9.7-10.8%)
- Mood disturbance (9.1-10.9%)
- Headache (4.8-6.3%)
- Breast symptoms (5.3-5.4%)
- Dysmenorrhea (3.7-4.1%)
- Weight increased (3-3.3%)
- Acne (3.2-3.7%)
- Libido decreased/lost (1.3-2%)
- Depression (1.7%)
- Thromboembolic event reported in a female who had been taking therapy for 75 days and had normal BMI Less than 25 kg/m2
Drug Interaction
Drug Interaction
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Disease Interaction
Disease Interaction
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Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
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Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.