Indication
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Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Reflux oesophagitis Age: Adult |
Dose: Oral – 20 mg Frequency: once daily Duration: 4 weeks, may be followed by a further 4 weeks if necessary |
|
Indication: Maintenance therapy of healing in patients with repeat recurrence or relapse Age: Adult |
Dose: Oral – 10 mg Frequency: once daily Note: may be increased to 20 mg once daily if needed |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Not available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Patients with renal disorders |
Dose: Vonoprazan – Not specified Note: Administer with care as a delay in the excretion of Vonoprazan may occur, which may result in an increase in the concentration of Vonoprazan in the blood. |
Administration
Vonoprazan is administered orally as a tablet and can be taken with or without food. The tablet should be swallowed whole with water and must not be crushed or chewed. It is typically taken once daily. No specific dose adjustments are required for mild to moderate renal or hepatic impairment, but caution and potential dose reductions are advised in severe cases. Precautions include monitoring for an increased risk of Clostridium difficile-associated diarrhea, potential bone fractures with long-term use, and severe hypomagnesemia. It is not indicated for pediatric populations. Elderly patients generally require no specific dose adjustments but should be monitored closely for adverse gastrointestinal effects and potential drug interactions, particularly with medications whose absorption is dependent on gastric pH.
Side Effect
- Clostridioides difficile-associated infection, pseudomembranous colitis, increased intragastric pH, benign gastric polyps (prolonged use)
- increased risk of hip, spine, or wrist osteoporosis-related fractures (long-term use or high doses)
- hepatic function abnormalities, including liver injury. Rarely, hypomagnesaemia (prolonged use)
- Diarrhoea, constipation, nausea, abdominal distention or discomfort, stomatitis, taste abnormality
- Jaundice
- Hypersensitivity reactions (e.g. urticaria, anaphylactic shock)
- Increased AST, ALT, and gamma-glutamyl transferase
- Rash, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug eruption
Drug Interaction
Drug Interaction
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Disease Interaction
Disease Interaction
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Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
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Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.