Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension |
Dose: Tablet – Initial: 2.5 mg Frequency: once daily Note: May increase to up to 5 mg by mouth once daily. Adjust dosage according to blood pressure goals. In general, wait 7-14 days between titration steps; titrate more rapidly if clinically warranted, provided the patient is assessed frequently. |
|
Indication: Hypertension Condition: Small, fragile, elderly, or hepatic insufficiency |
Dose: Tablet – 1.25 mg Frequency: once daily Note: This dose may also be used when adding to other antihypertensive therapy. Elderly patients and patients with hepatic insufficiency have decreased clearance of amlodipine with a resulting increase in AUC of \~40-60%, and a lower initial dose may be required. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: 6 to 17 years |
Dose: Oral – 1.25 mg to 2.5 mg Frequency: Once daily Note: Maximum Dose: 2.5 mg daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: Pharmacokinetics of amlodipine are not significantly influenced. No dosage adjustment required in patients with renal failure. |
Administration
- Take with or without food
- Take at regular intervals
Side Effect
- Edema (5.4-14.6%)
- Fatigue (4.5%)
- Flushing (1.5-4.5%)
- Palpitations (0.7-4.5%)
- Dizziness (1.1-3.4%)
- Palpitations (1.4-3.3%)
- Nausea (2.9%)
- Flushing (0.7-2.6%)
- Abdominal pain (1.6%)
- Somnolence (1.3-1.6%)
- Somnolence (1.4%)
- Cardiovascular Arrhythmia (eg ventricular tachycardia, atrial fibrillation)
- bradycardia
- chest pain
- peripheral ischemia
- syncope
- tachycardia
- vasculitis
- Central and peripheral nervous system Hypoesthesia
- neuropathy peripheral
- paresthesia
- tremor
- vertigo
- Gastrointestinal Anorexia
- constipation
- dysphagia
- diarrhea
- flatulence
- pancreatitis
- vomiting
- gingival hyperplasia
- General Allergic reaction
- asthenia
- back pain
- hot flushes
- malaise
- pain
- rigors
- weight gain
- weight decrease
- Musculoskeletal system Arthralgia
- arthrosis
- muscle cramps
- myalgia
- Psychiatric Sexual dysfunction (male and female)
- insomnia
- nervousness
- depression
- abnormal dreams
- anxiety
- depersonalization
- Respiratory system Dyspnea
- epistaxis
- Skin and appendages Angioedema
- erythema multiforme
- pruritus
- rash
- erythematous rash
- maculopapular rash
- Special senses Abnormal vision
- conjunctivitis
- diplopia
- eye pain
- tinnitus
- Urinary system Micturition frequency
- micturition disorder
- nocturia
- Autonomic nervous system Dry mouth
- sweating increased
- Metabolic and nutritional Hyperglycemia
- thirst
- Hemopoietic Leukopenia
- purpura
- thrombocytopenia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A inhibitors
|
Increased systemic exposure
|
|
CYP3A inducers
|
Monitor blood pressure closely
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store bottles at 20°C to 25°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.