Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Drug-induced extrapyramidal symptoms Age: Adult |
Dose: Oral – 5-15 mg/day Frequency: divided every 6-8 hours Note: administered by mouth |
|
Indication: Parkinson Disease Age: Adult |
Dose: Oral – Initially, 1 mg daily, gradually increased at intervals of 3-5 days by increments of 2 mg until 6-10 mg daily Frequency: in 3-4 divided doses Note: administered by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy – not established Note: Safety and efficacy not established |
Administration
- Take with food
- Take before meals if dry mouth occurs
Side Effect
- Anticholinergic side effects (30-50%)
- Rash
- Suppurative parotitis
- Hallucination
- Paralytic ileus
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Phenothiazines, clozapine, Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), disopyramide, nefopam, amantadine
|
Increased antimuscarinic side effects
|
|
TCAs
|
Synergistic effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Closed-Angle Glaucoma
|
Can increase eye pressure
|
|
Chronic Pulmonary Disease
|
Can worsen breathing
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.