Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Management of Pseudomonas aeruginosa in patients with cystic fibrosis Age: Adult |
Dose: Inhalation – One single-use ampoule (300 mg) Frequency: every 12 hours Duration: inhaled from a suitable nebuliser for 28 days, then stop for 28 days and repeat in cycles of 28 days as needed |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: management of Pseudomonas aeruginosa in patients with cystic fibrosis Age: greater than 6 years |
Dose: Inhalation Solution – 300 mg Frequency: every 12 hours Duration: 28 days, then stop for 28 days and repeat in cycles of 28 days as needed Note: inhaled from a suitable nebulizer |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Form – Not specified Note: Dosage adjustment needed |
Administration
- Follow prescribed route of administration
- Complete full course
Side Effect
- Voice alteration (12.8%)
- Myalgia (4.7%)
- Laryngitis (4.3%)
- Tinnitus (3%)
- Epistaxis (3%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Etacrynic acid, Furosemide, Other aminoglycosides, Cefalotin, Cisplatin, Vancomycin, Piperacillin, Ciclosporin, Amphotericin B
|
Increased nephrotoxicity or ototoxicity
|
|
Miconazole
|
Decrease serum tobramycin levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Aminoglycoside Hypersensitivity
|
Risk of severe allergic reaction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store under refrigeration at 2-8° C, and protected from light. Slight color change when unrefrigerated do not indicate any change in the quality of the product. The preparation must not be used if it is cloudy, particles appear in the solution or has been stored at room temperature for over 28 dyas. For use only under the prescription of a registered physician. Do not use Tobasol® beyond the expiration date stamped on the ampoule.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.