Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypercholesterolemia, Hypertriglyceridemia, hyperlipidemia, mixed dyslipidemia, Prophylaxis of cardiovascular events in high-risk patients Age: Adult |
Dose: Oral – 5 or 10 mg Frequency: once daily Note: May increase dose at 4-weekly intervals to 20 mg daily if necessary. Maximum: 40 mg once daily. Active liver disease: Use is contraindicated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Heterozygous familial hypercholesterolaemia Age: Child greater than 10 years |
Dose: Oral – Initially, 5 mg Frequency: once daily Note: may be adjusted at intervals of at least 4 weeks. Maximum: 20 mg once daily. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Severe (Creatinine Clearance less than 30 mL/min/1.73m²) and not on hemodialysis |
Dose: by mouth – 5 mg Frequency: once daily Note: Decrease starting dose to 5 mg by mouth once daily; not to exceed 10 mg by mouth once daily |
|
Condition: Creatinine Clearance greater than 30 mL/min/1.73m² |
Dose: by mouth Note: Dose adjustment not necessary |
Administration
- Can be taken with or without food
- Take at same time daily
Side Effect
- Myalgia (3-13%)
- Arthralgia (10%)
- Diabetes mellitus
- new onset (3%)
- Pharyngitis (9%)
- Headache (6%)
- Asthenia (up to 5%)
- Dizziness (4%)
- CPK increased (3%)
- Nausea (3%)
- Abdominal pain (2%)
- ALT increased (2%)
- Constipation (2%)
- Flulike illness (2%)
- UTI (2%)
- Jaundice
- Myopathy
- Rhabdomyolysis
- Rhabdomyolysis with acute renal failure
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Warfarin, Oral contraceptives
|
May increase serum levels
|
|
Itraconazole, HIV Protease Inhibitors (Ritonavir, Atazanavir, Lopinavir, Nelfinavir, Saquinavir, Indinavir)
|
May increase serum levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Impairment
|
Risk of muscle damage
|
|
Active Liver Disease
|
Can worsen liver function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.