Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Atrial Fibrillation Condition: Rapid digitalizing (loading-dose) regimen |
Dose: by mouth – 10-15 micrograms/kilogram total loading dose Frequency: administer 50% initially; then may cautiously give 1/4 the loading dose every 6-8 hours twice Note: perform careful assessment of clinical response and toxicity before each dose |
|
Indication: Atrial Fibrillation Condition: Maintenance |
Dose: by mouth – 3.4-5.1 micrograms/kilogram/day or 0.125-0.5 milligrams/day Note: may increase dose every 2 weeks based on clinical response, serum drug levels, and toxicity |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Heart Failure or Atrial Fibrillation Condition: Heart Failure |
Dose: Oral – Use doses at the lower end of the spectrum Note: Reduce dose by 20-25% when changing from oral formulation or intramuscular to intravenous therapy |
|
Age: Premature neonate |
Dose: Oral – 1st loading dose: 10-15 mcg/kg Note: 2nd and 3rd loading doses: 5-7.5 mcg/kg every 6-8 hours for 2 doses |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Impaired renal function |
Dose: – 0.125 mg/day Note: Use lower end of dosing in patients with impaired renal function |
Administration
- May be taken with or without food
- Take at same time each day
Side Effect
- Dizziness (4.9%)
- Mental disturbances (4.1%)
- Diarrhea (3.2%)
- Headache (3.2%)
- Nausea (3.2%)
- Vomiting (1.6%)
- Maculopapular rash (1.6%)
- Anorexia
- Cardiac dysrhythmia
- Arrhythmia in children (consider a toxicity)
- Visual disturbance (blurred or yellow vision)
- Heart block (1°/2°/3°)
- Asystole
- Tachycardia
- Cardiac arrhythmias in combination with heart block
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Phenytoin, Neomycin, Sulphasalazine, Kaolin, Pectin, Antacids
|
Effectiveness reduced
|
|
Metoclopramide
|
May alter the absorption of solid dosage forms of digoxin
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Digitalis Toxicity
|
Risk of overdose
|
|
Ventricular Tachycardia
|
Can worsen heart rhythm
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place.Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.