Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Osteoarthritis Condition: Initial in mild to moderate disease |
Dose: Oral – 600 mg Frequency: once daily |
|
Indication: Osteoarthritis Condition: Usual in moderate to severe disease |
Dose: Oral – 1200 mg Frequency: once daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Juvenile Rheumatoid Arthritis Age: less than 6 years |
Dose: PO – Dosage not established Note: Safety and efficacy not established |
|
Indication: Juvenile Rheumatoid Arthritis Age: greater than 6 years |
Dose: PO – 600 mg Frequency: once daily Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Severe renal impairment or on dialysis |
Dose: by mouth – 600 mg Frequency: once daily Note: may increase to 1200 mg/day; monitor closely |
Administration
- Take with food or water
- Take with full glass of water
Side Effect
- Edema
- Rash
- Abdominal pain
- Anorexia
- Constipation
- Diarrhea
- Indigestion
- Nausea/Vomiting
- GI ulcer
- Gross bleeding with perforation
- Heartburn
- Anemia
- LFT's increased
- Tinnitus
- Dysuria
- Increased frequency of urination
- Myocardial infarction (Less than 2%)
- Hypertension (Less than 1%)
- Palpitations (Less than 1%)
- Thrombotic tendency observations
- Erythema multiforme (rare)
- Scaling eczema
- Stevens-Johnson syndrome (rare)
- Toxic epidermal necrolysis (rare)
- Cerebrovascular accident
- Gastrointestinal hemorrhage (Less than 1%)
- Agranulocytosis (rare)
- Leukopenia (Less than 1%)
- Thrombocytopenia (Less than 1%)
- Hepatitis (rare)
- Jaundice
- Liver failure
- Anaphylactoid reaction (Less than 1%)
- Amblyopia (Less than 1%)
- Hearing loss (Less than 1%)
- Acute renal failure (rare)
- Hematuria (rare)
- Interstitial nephritis (rare)
- Bronchospasm
- Serum sickness due to drug (rare)
- Anaphylactoid reactions
- exfoliative dermatitis
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- severe hepatic reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aspirin
|
Increased risk of salicylate toxicity
|
|
Oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May increase effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Previous/Active Peptic Ulcer
|
Risk of GI bleeding
|
|
CABG Surgery
|
Risk of cardiovascular events
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25° C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.