Medicine Overview

Indication

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Adult Dose

Clinical InformationAdministration Information
Indication: Type 2 diabetes mellitus
Age: Adult
Dose: Oral – Initially, 2.5-5 mg
Frequency: daily
Note: Initially given as a single dose. Adjust at intervals of several days in increments of 2.5-5 mg daily. Doses greater than 15 mg may be given in 2 divided doses. Maximum: 40 mg daily.
Indication: Type 2 diabetes mellitus
Age: Adult
Dose: Extended-release tablets – Initial: 5 mg/day
Frequency: once daily
Note: Given by mouth with breakfast; dose adjustment based on blood glucose should not be done more frequently than every 7 days.

Child Dose

Clinical InformationAdministration Information
Age: Pediatric
Dose: Tablet – Safety and efficacy not established

Renal Dose

Clinical InformationAdministration Information
Condition: Renal impairment: glomerular filtration rate less than 50 mL/min
Dose: Not specified – decrease dose by 50%
Note: Renal impairment: Not studied; if glomerular filtration rate less than 50 mL/min, may decrease dose by 50%
Condition: Severe renal impairment
Dose: Not specified – Contraindicated
Note: Severe: Contraindicated.
Administration
  • Take 30min before meals
  • Don't skip meals
Side Effect

Drug Interaction

Drug NameRisk Factors
Antifungals (e.g. miconazole, fluconazole)
Increased plasma concentration
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Other sulfonamides, Oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban), Hydantoins, Probenecid, MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide), Chloramphenicol
May potentiate hypoglycaemic action

Disease Interaction

Disease NameRisk Factors
Type 1 DM
Ineffective treatment
Ketoacidosis
Can worsen metabolic state

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
The tablets should be protected from moisture and humidity and stored at room temperature (below 30° C).

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.