Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV infection Age: Adult |
Dose: Tablet – lamivudine 150 mg and zidovudine 300 mg Frequency: twice daily Note: Avoid administering to patients weighing less than 30 kg because each tablet contains a fixed dose. |
|
Indication: HIV infection Age: Adult Condition: Severe hepatic impairment |
Dose: Oral preparation Note: Not recommended; use separate preparations. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV Infection Age: less than 12 years |
Dose: Tablet – Not recommended Note: fixed-dose combination cannot be adjusted for children |
|
Indication: HIV Infection Age: greater than 12 years |
Dose: Tablet – Not recommended Note: fixed-dose combination cannot be adjusted for children |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance (ml/min) less than 50 |
Dose: Dosage Recommendation – Not recommended, use separate preparations Note: Renal impairment: Creatinine Clearance (ml/min) less than 50 Not recommended, use separate preparations |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Headache (35%)
- Nausea (33%)
- Malaise & fatigue (27%)
- Cough (18%)
- Diarrhea (18%)
- Vomiting (13%)
- Musculoskeletal pain (12%)
- Neuropathy (12%)
- Insomnia & other sleep disorders (11%)
- Anorexia &/or decreased appetite (10%)
- Dizziness (10%)
- Fever or chills (10%)
- Abdominal pain (9%)
- Depressive disorders (9%)
- Skin rashes (9%)
- Myalgia (8%)
- Neutropenia (7.2%)
- Abdominal cramps (6%)
- Arthralgia (5%)
- Dyspepsia (5%)
- Anemia (2.9%)
- Erythema multiforme
- Stevens-Johnson syndrome
- Lactic acidosis
- Pancreatitis
- Hepatomegaly (Severe)
- Steatosis of liver (Severe)
- Anaphylaxis
- Immune hypersensitivity reaction
- Rhabdomyolysis
- Lactic acidosis associated with liver failure and pancreatitis (normally after several month of treatment)
- haematological toxicity (eg neutropenia and severe anaemia)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Same as Lamivudine + Nevirapine + Zidovudine
|
Same effects as Lamivudine + Nevirapine + Zidovudine
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Neutrophil count <0.75 x 109/L
|
High risk of infections
|
|
Hemoglobin levels <5 g/dL
|
Severe anemia risk
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Stored at a cool and dry place, protected from light and moisture. Keep the medicine out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.