Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Epilepsy Age: Adult |
Dose: Oral – 3-4 mg/kg Frequency: once daily or in divided doses Note: Initially |
|
Indication: Epilepsy Age: Adult |
Dose: Oral – 150-300 mg Frequency: once daily Note: Alternative initial dose; increased gradually to 600 mg daily if necessary |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Control of Tonic-Clonic and Complex Partial Seizures Age: Neonates Condition: Initial dosage |
Dose: Oral – 5 mg/kg/day Frequency: in 2 divided doses Note: by mouth (oral) |
|
Indication: Control of Tonic-Clonic and Complex Partial Seizures Age: 6 months to 16 years Condition: Initial dosage |
Dose: Oral – 5 mg/kg/day Frequency: in 2-3 divided doses Note: by mouth (oral) |
Administration
- Take with food
- Space doses evenly
Side Effect
- Hypersensitivity
- lack of appetite
- headache
- dizziness
- tremor
- transient nervousness
- insomnia
- GI disturbances (eg nausea
- vomiting
- constipation)
- tenderness and hyperplasia of the gums
- acne
- hirsutism
- coarsening of the facial features
- rashes
- osteomalacia
- Phenytoin toxicity as manifested as a syndrome of cerebellar
- vestibular
- ocular effects
- notably nystagmus
- diplopia
- slurred speech
- and ataxia
- also with mental confusion
- dyskinesias
- exacerbations of seizure frequency
- hyperglycaemia
- Solutions for Injection may cause local irritation or phlebitis
- Prolonged use may produce subtle effects on mental function and cognition
- especially in children
- Toxic epidermal necrolysis
- Stevens-Johnson syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Other sedative drugs, Ethanol
|
Effects may be potentiated
|
|
Paracetamol, Lithium
|
Enhances toxic effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.