Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prophylaxis of migraine Age: Adult |
Dose: Oral – Initially, 0.5 mg Note: Increase gradually as necessary. Maximum: 4.5 mg daily (maximum less than 3 mg/dose). Hepatic impairment: Dose adjustment may be needed. |
|
Indication: Prophylaxis of migraine Age: Adult Condition: Maintenance |
Dose: Oral – 1.5 mg Frequency: Daily as a single dose at night or in 3 divided doses Note: Maximum: 4.5 mg daily (maximum less than 3 mg/dose). Hepatic impairment: Dose adjustment may be needed. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prophylaxis of migraine Age: greater than 2 years |
Dose: Oral – Initially, 0.5 mg Frequency: once daily Note: May increase gradually up to 1.5 mg daily in divided doses (maximum 1 mg/dose) |
|
Indication: Prophylaxis of cluster headache Age: greater than 2 years |
Dose: Oral – Initially, 0.5 mg Frequency: once daily Note: May increase gradually up to 1.5 mg daily in divided doses (maximum 1 mg/dose) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: Dose adjustment may be needed. |
Administration
- May be taken with or without food
- Take at bedtime
Side Effect
- Increased appetite
- nausea
- weight gain
- drowsiness
- dizziness
- dry mouth
- fatigue
- muscle pain or cramps
- heavy or restless legs
- fluid retention
- facial flushing
- reduced libido
- exacerbation of epilepsy
- dreaming
- hepatic injury
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CNS depressants
|
Enhances sedative effects
|
|
Other antimuscarinic drugs
|
Additive antimuscarinic action
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Postural Giddiness
|
Can worsen dizziness
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.