Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Myasthenia gravis Age: Adult |
Dose: Oral – 30-120 mg Frequency: in divided doses Note: Up to a total daily dose of 0.3-1.2 g. |
|
Indication: Paralytic ileus and postoperative urinary retention Age: Adult |
Dose: Oral – 60-240 mg Frequency: daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Myasthenia gravis Age: less than 6 yr |
Dose: Oral – Initially, 30 mg Frequency: repeated throughout the day Note: usual total daily dose of 30-360 mg, with increments of 15-30 mg daily until a satisfactory response is obtained |
|
Indication: Myasthenia gravis Age: 6-12 yr |
Dose: Oral – Initially, 60 mg Frequency: repeated throughout the day Note: usual total daily dose of 30-360 mg, with increments of 15-30 mg daily until a satisfactory response is obtained |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Lower initial dose Note: Lower initial dose may be needed, titrate to desired effect. |
Administration
- Take with food
- Space doses evenly throughout day
Side Effect
- Nausea
- vomiting
- diarrhoea
- increased peristalsis and bronchial secretions
- miosis
- excessive salivation and sweating
- abdominal cramps
- bradycardia
- bronchospasm
- skin rash
- muscle spasm
- fasciculation
- muscle weakness
- Resp paralysis
- cardiac arrest
- pulmonary oedema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Anti-glaucoma drugs
|
May exacerbate night vision problems
|
|
Non-depolarising Muscle Relaxants (Baclofen, Cyclobenzaprine, Tizanidine, Dantrolene)
|
Antagonises effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Mechanical GI/Urinary Obstruction
|
Can worsen blockage
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in cool and dry place, protected from light. Keep out of children’s reach.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.