Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Osteoporosis Age: Postmenopausal women Condition: Prevention |
Dose: Tablet – 5 mg Frequency: once daily Note: by mouth |
|
Indication: Osteoporosis Age: Postmenopausal women Condition: Prevention |
Dose: Tablet – 35 mg Frequency: once weekly Note: by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild-to-moderate renal impairment (CrCl 35-60 mL/min) |
Dose: Dose: Note: Dose adjustment not necessary |
|
Condition: Severe renal impairment (CrCl less than 35 mL/min) |
Dose: Dose: Note: Not recommended |
Administration
- Take on empty stomach with water
- Stay upright for 30 minutes after
Side Effect
- Hypocalcemia, transient and mild (18%)
- Hypophosphatemia, transient and mild (10%)
- Abdominal pain (7%)
- Musculoskeletal pain (4.1%)
- Dyspepsia (3.6%)
- Nausea (3.6%)
- Constipation (3.1%)
- Diarrhea (3.1%)
- Flatulence (2.6%)
- Headache (2.6%)
- Acid regurgitation (2%)
- Esophagitis (1.5%)
- Abdominal distention (1%)
- Alopecia
- Diaphyseal femur fracture
- Esophageal cancer
- Flu like syndrome
- Gastritis
- Myalgia
- Oropharyngeal ulceration
- Pruritus
- Rash
- Taste perversion
- Toxic epidermal necrolysis
- Uveitis
- Vertigo
- Weakness
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Iron, Calcium supplements, Antacids
|
Hinder alendronate absorption
|
|
Aspirin, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
May increase the incidence of adverse GI effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypocalcaemia
|
Risk of calcium imbalance
|
|
Oesophageal Abnormalities
|
Risk of esophageal damage
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a well-closed container at room temperature, 15-30°C
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.