Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Gout; Hyperuricaemia Age: Adult |
Dose: Oral – 100 mg Frequency: once daily Note: Increase by 100 mg weekly increments until serum uric acid of 6 mg/dl or less is reached (maximum 800 mg daily). |
|
Indication: Hyperuricemia Associated with Cancer Therapy Age: Adult Condition: Prevention of hyperuricemia associated with chemotherapy treatment or enzyme disorders |
Dose: Oral – 300 mg to 800 mg Frequency: once daily Note: Starting 2-3 days before cancer treatment. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hyperuricemia Associated with Cancer Therapy Age: Pediatric |
Dose: orally – 100 mg/m2 Frequency: every 8 hours to 12 hours Note: 10 mg/kg/day, maximum 800 mg/day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment eGFR greater than 60 mL/minute |
Dose: – Note: No dosage modification |
|
Condition: Renal impairment eGFR greater than 30 to 60 mL/minute |
Dose: – 50 mg Frequency: daily |
Administration
- Take with food
- Drink plenty of water
Side Effect
- Rash (1.5%)
- Nausea (1.3%)
- Renal failure (1.2%)
- Vomiting (1.2%)
- Amblyopia
- Arthralgias
- Blood dyscrasias
- Bronchospasm
- Cardiovascular abnormalities
- Cataracts
- Confusion
- Decrease in libido
- Dizziness
- Ecchymosis
- Electrolyte abnormalities
- Epistaxis
- Foot drop
- Hematuria
- Hepatotoxicity
- Hypotonia
- Iritis
- Kidney function abnormality
- Macular retinitis
- Malaise
- Neuritis
- Pharyngitis
- Pruritus
- Skin edema
- Stevens-Johnson syndrome
- Sweating
- Tinnitus
- Stevens-Jonhson and/or Lyell's Syndrome (urticaria, fever, lymphadenopathy, arthralgia)
- Occasionally, thrombocytopaenia
- agranulocytosis and aplastic anaemia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Mercaptopurine, Azathioprine
|
May inhibit the metabolism
|
|
Warfarin, Other coumarin Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May increase effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute Attack of Gout
|
Can worsen gout attack
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.