Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Major Depressive Disorder Age: Adult |
Dose: Oral – Initially, 20-30 mg or 60 mg Frequency: twice daily or once daily Note: Increase dose in increments of 30 mg/day over 1 week as tolerated. Maximum: 120 mg/day. |
|
Indication: Diabetic Peripheral Neuropathic Pain Age: Adult |
Dose: Oral – 60 mg Frequency: once daily Note: Maximum: 120 mg/day in divided doses. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Generalized Anxiety Disorder Age: less than 7 years |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: Generalized Anxiety Disorder Age: 7-17 years |
Dose: by mouth (oral) – 30 mg Frequency: once daily Note: initially; after 2 weeks, may consider increasing dose to 60 mg/day; Recommended dosage range: 30-60 mg/day; Some patients may benefit from doses greater than 60 mg/day; if increased beyond 60 mg/day, use increments of 30 mg/day; Maximum dose studied was 120 mg/day; safety of doses greater than 120 mg/day has not been evaluated |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment (Glomerular Filtration Rate less than 30 mL/minute) |
Dose: Not specified Note: Avoid use in patients with severe renal impairment (Glomerular Filtration Rate less than 30 mL/minute) |
Administration
- May take with or without food
- Swallow whole
Side Effect
- Nausea (23-25%)
- Dry mouth (13-15%)
- Headache (13-14%)
- Somnolence (10-12%)
- Fatigue (10-11%)
- Constipation (10%)
- Dizziness (10%)
- Insomnia (10%)
- Diarrhea (9-10%)
- Anorexia (8%)
- Decreased appetite (7-8%)
- Abdominal pain (6%)
- Hyperhidrosis (6%)
- Increased sweating (6%)
- Agitation (5%)
- Nasopharyngitis (5%)
- Vomiting (3-5%)
- Male sexual dysfunction (2-5%)
- Abdominal pain (4%)
- Decreased libido (4%)
- Musculoskeletal pain (4%)
- Upper respiratory tract infection (URTI) (URTI) (4%)
- Abnormal orgasm (3%)
- Agitation (3%)
- Anxiety (3%)
- Blurred vision (3%)
- Cough (3%)
- Influenza (3%)
- Muscle spasms (3%)
- Tremor (3%)
- Abnormal dreams (2%)
- Dyspepsia (2%)
- Hot flushes (2%)
- Nausea (2%)
- Oropharyngeal pain (2%)
- Palpitations (2%)
- Paresthesia (2%)
- Weight loss (2%)
- Yawning (2%)
- Dysuria (More than 1%)
- Gastritis (More than 1%)
- Rash (More than 1%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
TCA, SSRI, SNRI, Lithium
|
Increased risk of serotonin syndrome
|
|
Aspirin, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Warfarin, Other Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May increase bleeding risk
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Uncontrolled Narrow-Angle Glaucoma
|
Can increase intraocular pressure
|
|
Renal Impairment
|
Can worsen kidney function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.