Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: GERD Without Erosive Esophagitis Age: Adult |
Dose: by mouth – 20 mg Frequency: once daily Duration: for 4 weeks Note: consider an additional 4 weeks of treatment if symptoms do not resolve completely in the first 4 weeks |
|
Indication: GERD With Erosive Esophagitis Age: Adult |
Dose: by mouth – 20-40 mg Frequency: once daily Duration: for 4-8 weeks |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: GERD Without Erosive Esophagitis Age: less than 1 year |
Dose: Oral – Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: GERD Without Erosive Esophagitis Age: 1-12 years |
Dose: Oral – 10-20 mg Frequency: once daily Duration: up to 8 weeks Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Tablet – Dosage adjustment not needed Note: Renal impairment: No dosage adjustment needed. |
Administration
- Take without food
- Take 30 minutes before meals
Side Effect
- Headache (2-11%)
- Flatulence (10%)
- Indigestion (6%)
- Nausea (6%)
- Abdominal pain (1-6%)
- Diarrhea (2-4%)
- Xerostomia (3-4%)
- Dizziness (2-3%)
- Constipation (2-3%)
- Somnolence (1-2%)
- Pruritus (1%)
- Blood and lymphatic system disorders Agranulocytosis
- pancytopenia
- Blurred vision
- GI disorders Pancreatitis
- stomatitis
- microscopic colitis
- Hepatobiliary disorders Hepatic failure
- hepatitis with or without jaundice Anaphylactic reaction/shock
- GI candidiasis
- Hypomagnesemia
- Musculoskeletal disorders Muscular weakness
- myalgia
- bone fracture
- Nervous system disorders Hepatic encephalopathy
- taste disturbance
- Psychiatric disorders Aggression
- agitation
- depression
- hallucination
- Interstitial nephritis
- Gynecomastia
- Bronchospasm
- Skin and subcutaneous tissue disorders Alopecia
- erythema multiforme
- hyperhidrosis
- photosensitivity
- Stevens-Johnson syndrome
- toxic epidermal necrolysis (sometimes fatal fatal)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Digoxin
|
Increased risk of digoxin-induced cardiotoxic effects
|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene)
|
Increased risk of hypomagnesaemia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at a temperature not exceeding 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.