Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Status epilepticus; Emergency management of acute seizures Age: Adult |
Dose: Intravenous – 200-600 mg Note: As phenobarbital sodium. |
|
Indication: Status epilepticus; Emergency management of acute seizures Age: Adult |
Dose: Intravenous – 15-18 mg/kg Frequency: Loading dose infused at 25-60 mg/minute Note: Prepare to support ventilation; may repeat in 20-minute intervals as needed; not to exceed 30 mg/kg. As phenobarbital sodium. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Status epilepticus; Emergency management of acute seizures Age: Child |
Dose: Parenteral – 100-400 mg Note: As phenobarbital sodium |
|
Indication: Status epilepticus; Emergency management of acute seizures Age: Infants and children |
Dose: Intravenous – 15-20 mg/kg Note: Infused at a rate not to exceed 2 mg/kg/minute; not to exceed 1000 mg/dose; less than 60 kg: intravenous rate at less than 30 mg/minute; may repeat with 5-10 mg/kg bolus dose after 15-30 minutes as needed; not to exceed cumulative dose of 40 mg/kg |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified – Reduce dose Note: Severe renal impairment: Contraindicated. |
Administration
- For IV/IM use only
- Give slowly
Side Effect
- Ataxia
- Dizziness
- Drowsiness
- Dysarthria
- Fatigue
- Headache
- Irritability
- Nystagmus
- Paresthesia restlessness
- Vertigo Geriatric patients Excitement
- confusion
- depression
- Pediatric patients Paradoxical excitement/hyperactivity
- Mental dullness
- Constipation
- Diarrhea
- Nausea
- Vomiting
- Megaloblastic (folate-deficiency) anemia
- Rash
- Hypocalcemia
- Hepatotoxicity
- Stevens-Johnson syndrome
- Rickets
- Osteomalacia
- Stevens-Johnson syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Paracetamol
|
May enhance hepatotoxic potential of overdoses
|
|
Various CYP isoenzyme substrates
|
May decrease levels/effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Disorders
|
Risk of drug accumulation
|
|
Severe Hepatic Disorders
|
Impaired drug metabolism
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.