Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Minor dermatological procedures (e.g. intravenous cannulation or venipuncture) |
Dose: Cream – 2.5 g Duration: at least 1 hour Note: Apply over 20-25 square centimeters of skin surface area. |
|
Indication: Painful dermatological procedures involving large areas (e.g. split thickness skin graft harvesting) |
Dose: Cream – 2 g / 10 square centimeters of skin Duration: at least 2 hours Note: Allow to remain in contact with the skin. Analgesia is achieved in 1 hour, reaches maximum in 2-3 hours, and persists 1-2 hours after removal. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Local Anesthetic Procedures Age: Neonates (gestation age less than 37 weeks) |
Dose: Cream Note: Use not recommended |
|
Indication: Local Anesthetic Procedures Age: less than 12 months |
Dose: Cream Note: Do not use if receiving treatment with methemoglobinemia-inducing agents |
Administration
- Clean area first
- Apply thick layer
Side Effect
- Pallor/blanching (37%)
- Application site erythema/pain (30%)
- Genital mucous membrane burning sensation (17%)
- Oral cavity
- periodontal formulation (15%)
- Alterations in temperature sensations (7%)
- Application site edema (6-10%)
- Itching (2%)
- Rash
- Myocardial dysfunction (rare)
- Methemoglobinemia (rare)
- Depression/excitation (rare)
- Seizure (rare)
- Localized discrete purpuric or petechial reactions (rare)
- Localized hyperpigmentation (rare)
- Allergic reactions (eg urticaria, angioedema, bronchospasm, shock)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Drugs that cause methaemoglobinaemia
|
Increased risk of toxicity
|
|
Class III Antiarrhythmics (Amiodarone, Flecainide, Propafenone, Quinidine, Disopyramide, Procainamide)
|
Additive cardiac effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Application on mucous membranes
|
Risk of absorption toxicity
|
|
Broken or inflamed skin
|
Increased absorption risk
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.